Motor fluctuations and dyskinesias in Parkinson's disease: Clinical manifestations
Identifieur interne : 002D05 ( Main/Corpus ); précédent : 002D04; suivant : 002D06Motor fluctuations and dyskinesias in Parkinson's disease: Clinical manifestations
Auteurs : Joseph JankovicSource :
- Movement Disorders [ 0885-3185 ] ; 2005-05.
English descriptors
Abstract
Fluctuations in the symptoms of Parkinson's disease (PD), such as wearing‐off and on–off effects, and dyskinesias are related to a variety of factors, including duration and dosage of levodopa, age at onset, stress, sleep, food intake, and other pharmacokinetic and pharmacodynamic mechanisms. The majority of patients, particularly those with young onset of PD, experience these levodopa‐related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called “peak‐dose dyskinesia”, usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less‐common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing‐off effect. Recognition of the full spectrum of clinical phenomenology of levodopa‐related motor complications is essential for their treatment and prevention. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20458
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ISTEX:417B2C39FC316CDACC5B249649EB08D90DA7E8AFLe document en format XML
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The majority of patients, particularly those with young onset of PD, experience these levodopa‐related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called “peak‐dose dyskinesia”, usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less‐common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing‐off effect. 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The majority of patients, particularly those with young onset of PD, experience these levodopa‐related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called “peak‐dose dyskinesia”, usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less‐common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing‐off effect. 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The majority of patients, particularly those with young onset of PD, experience these levodopa‐related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called “peak‐dose dyskinesia”, usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less‐common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing‐off effect. Recognition of the full spectrum of clinical phenomenology of levodopa‐related motor complications is essential for their treatment and prevention. © 2005 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Motor fluctuations and dyskinesias in Parkinson's disease: Clinical manifestations</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Clinical Motor Fluctuations and Dyskinesias</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Motor fluctuations and dyskinesias in Parkinson's disease: Clinical manifestations</title></titleInfo><name type="personal"><namePart type="given">Joseph</namePart><namePart type="family">Jankovic</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><description>Correspondence: Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-05</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">66</extent><extent unit="words">3979</extent></physicalDescription><abstract lang="en">Fluctuations in the symptoms of Parkinson's disease (PD), such as wearing‐off and on–off effects, and dyskinesias are related to a variety of factors, including duration and dosage of levodopa, age at onset, stress, sleep, food intake, and other pharmacokinetic and pharmacodynamic mechanisms. The majority of patients, particularly those with young onset of PD, experience these levodopa‐related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called “peak‐dose dyskinesia”, usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less‐common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing‐off effect. Recognition of the full spectrum of clinical phenomenology of levodopa‐related motor complications is essential for their treatment and prevention. © 2005 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>motor complications</topic><topic>Parkinson's disease</topic><topic>dyskinesia</topic><topic>wearing off</topic><topic>levodopa</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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